Aldosterone is a hormone that controls salt and potassium levels in the blood. Common conditions that can cause too much aldosterone include. Conn syndrome, also known as primary hyperaldosteronism, is a condition of excess of aldosterone production and occurs secondary to adrenal cortical adenoma, bilateral adrenal hyperplasia, or rarely, adrenal carcinoma. The condition may result from the presence of an adenoma, carcinoma or enlargement of the adrenal gland or glands. An account of conns syndrome could begin with the first. Primary aldosteronism is present in about 10% of people with high blood pressure. Diagnosis and management of primary aldosteronism scielo. Claudia matta coelho1, ana margarida monteiro1, vera.
Full text is available as a scanned copy of the original print version. Conn s syndrome is a rare health problem that occurs when the adrenal glands make too much aldosterone. Primary aldosteronism conns syndrome cleveland clinic. Condition was first described at the university of michigan in 1955. Primary aldosteronism, also sometimes called conn syndrome, is an endocrine disorder characterized by excessive secretion of the hormone aldosterone from the adrenal glands. Primary aldosteronism also called conns syndrome is a rare condition caused by overproduction of the hormone aldosterone that controls sodium and potassium in the blood. The many faces of conns syndrome hypertension clinic. Often, it begins in those between 30 and 50 years of age. There are other, much rarer causes of primary aldosteronism, including. Conns syndrome symptoms, diagnosis, treatments and causes. Meme le medecin en charge du groupe nen revenait pas.
Jw conn primary aldosteronism, a new clinical syndrome. This overproduction leads to the retention of sodium and loss of potassium in the body, resulting in high blood pressure hypertension. Your adrenal glands produce a number of essential hormones, including aldosterone. Conns syndrome named after american endocrinologist jerome w.
Primary aldosteronism conn syndrome lab tests online. An uncommon but possible highly underdiagnosed condition characterized by the excessive production of a hormone called aldosterone by the adrenal gland. Feb 21, 2012 hyperaldosteronism is relatively uncommon but still accounts for about 0. The severity of the condition is variable with some. Earlier studies suggested that aldosteronomas was the more common cause of conns syndrome with a reported 7080% of all cases. Differentiation between the causes is required to avoid unnecessary surgery. This is usually due to the presence of a tumor in the adrenal cortex, the outer part of the adrenal gland. Primary aldosteronism endocrine and metabolic disorders. Primary aldosteronism is aldosteronism caused by autonomous production of aldosterone by the adrenal cortex due to hyperplasia, adenoma, or carcinoma. More than 50% are normokalaemic aetiology bilateral adrenal hyperplasia common discrete aldosteroneproducing adenoma.
Get a printable copy pdf file of the complete article 1. However recent epidemiologic research reveal that occurrence of hyperaldosteronism secondary to bilateral hyperplasia was higher than what was previously been. It has been estimated that only 9% to 37% of patients with primary al. Fulara and others published conns syndrome secondary to.
Symptoms and signs include episodic weakness, elevated blood pressure, and hypokalemia. Eating large amounts of real black licorice can produce a similar syndrome due to a chemical that acts like aldosterone. The condition is treated with medications and lifestyle changes to control blood pressure, and in some cases surgery. It occurs when your adrenal glands produce too much of a hormone called aldosterone. Hyperaldosteronism is a disease caused by an excess production of the normal adrenal hor mone aldosterone. Full text full text is available as a scanned copy of the original print version. Primary aldosteronism aldostuhronizum is a hormonal disorder that leads to high blood pressure. This problem is also known as primary hyperaldosteronism. Conn 19071994, an american endocrinologist who first described adenomas as a cause of the condition in 1955. Primary aldosteronism conns syndrome autonomous overproduction of aldosterone by the adrenal glands 12% of mild hypertension up to 20% of resistant hypertension hypokalaemia is a late and variable manifestation. Sommaire 1 causes 2 epidemiologie 3 physiopathologie 4 clinique 5 diagnostic 6 traitement 7 notes et references causes.
This hormone is responsible for sodium and potassium balance, which. Links to pubmed are also available for selected references. Secondary hyperaldosteronism is more common than primary. Conn s syndrome is a condition associated with the development of high blood pressure in the presence of low potassium levels in the blood. Primary aldosteronism symptoms and causes mayo clinic. Conn syndrome refers specifically to primary hyperaldosteronism due to an adrenal adenoma. Diagnosis includes measurement of plasma aldosterone levels and plasma renin activity.